MAFG is located in single cells and upregulated in sepsis in current study, showing a negative correlation with patient survival, suggesting that MAFG is a pathogenic gene and a potential intervention target.The researchers identified astrocytes in EAE and multiple sclerosis, which are increased MAFG expression, MAFG and MAT2 α Synergistically promote DNA methylation and inhibit antioxidant and anti-inflammatory transcriptional programs28. Here, MAFG is linked to multiple sclerosis.