Interestingly, although carrying osteoporosis phenotype (Fig. 9b, c, asterisks), the Brd9-depleted mouse showed resistant to LPS/ligation-stimulated local acute damage on the periodontal alveolar bone (Fig. 9b–d) and osteoclast activity (Fig. 9e, f) compared with the control mice. This evidence concerns the gene BRD9 and osteoporosis.