TNFSF11 and infection: The results showed that, without additional infection, loss of Brd9 led to slight inhibition on the basal expression of proinflammatory cytokines, such as TNF-α, iNOS, CD86, IL-1b with no apparent effect on RANKL in the femur bone tissue as shown with immunofluorescence staining, as well as the quantification analysis using qPCR (Supplementary Fig. 7).