The data indicated that the CCNE1-high, CCNE1-high/EGR1-low, CCNE1-high/SCGB3A1-low and OTX1-high/CCNE1-high phenotypes, which might be involved in lung cancer malignancy, are related to poor prognosis in lung cancer. The gene discussed is SCGB3A1; the disease is lung carcinoma.