TSPYL2 and cancer: Importantly, as demonstrated by proliferation and cell cycle profile analyses (Supplementary Fig. 1C-D), the variable TSPYL2 regulations are not due to significant differences in cell growth among the cell lines, nor to disparities in the physiological levels of this protein since, in untreated cancer cells, TSPYL2 exhibits sex-independent variable levels (Supplementary Fig. 1E).