H2AX and cancer: Importantly, we observed that TSPYL2 accumulates only in female and Y-negative male cancer cells retaining high levels of γ-H2AX at late time points after DNA damage (Fig. 1H), and that, in response to prolonged etoposide treatment, it shows a granular staining with some spots co-localizing with DNA damage induced γ-H2AX foci (Supplementary Fig. 1H).