SIRT7 and melanoma: Our analysis in a panel of melanoma cell lines and human primary melanocyte (HPM) revealed that both the mRNA and protein levels of SIRT7 were significantly increased in melanoma cells compared to HPM (Fig. 1f, g), which might be related to higher basal ER stress in melanoma than that in the melanocyte.28 Meanwhile, the level of ac-H3K18 was consistently reduced in melanoma cells (Fig. 1g), and there is a prominent negative correlation between SIRT7 level and ac-H3K18 level in melanoma cell lines and melanocytes (Fig. 1h).