Therefore, it can be proposed that NF-κB p65 might also indirectly promote PD-L1 expression via SIRT7 and its-mediated IRE1α-XBP1 axis, and this speculation might provide more evidence supporting the role of NF-κB p65 in anti-tumor immunity, which needs more investigation in the future. The gene discussed is ERN1; the disease is neoplasm.