Our present study has demonstrated that the up-regulation of SIRT7 is required for sustained PD-L1 expression in melanoma cells under the stressful circumstances, and targeting SIRT7 is a valuable strategy not only due to the direct suppressive effect on tumor growth via impairing tumor cell survival, but also the activation of CD8+T cells and anti-tumor immunity. This evidence concerns the gene SIRT7 and melanoma.