In parallel, the overexpression of SIRT7 in WM35 melanoma cell line resulted in up-regulation of IRE1α expression, IRE1α phosphorylation, spliced XBP1 expression, and HSPA5 expression caused by TM treatment, but marginal influence on ATF6 and phosphorylated-PERK (Fig. 3b). The gene discussed is XBP1; the disease is melanoma.