Targeting CSN5 by curcumin can diminish p65-induced PD-L1 up-regulation and sensitize cancer cells to anti-CTLA-4 antibody.64 Besides, different binding sequences for NF-κB have been described on the promoter of the PD-L1 gene,65 and NF-κB can directly promote PD-L1 expression at the transcriptional level to mediate immune evasion of cancer.66 Herein, we proved that stress-induced SIRT7 up-regulation was attributed to NF-κB p65-mediated transcriptional activation, and SIRT7 was required for tumorous PD-L1 expression up-regulation via the IRE1α-XBP1 axis under stress. This evidence concerns the gene COPS5 and cancer.