CD274 and neoplasm: The blockade of PD-L1/PD-1 is in position to disrupt the interaction between tumor cells and tumor-specific T cells, which can help to restore tumor-specific immune response.47 Surprisingly, while the knockdown of SIRT7 displayed a marginal effect on both the mRNA and protein levels of PD-L1 under normal conditions (Supplementary Fig. S8a), the deficiency of SIRT7 expression restrained TG-induced up-regulation of PD-L1 at both transcriptional and protein levels (Fig. 6a).