Besides, it has been reported that SIRT7 is necessary for a global hypoacetylation of H3K18Ac that is associated with cellular transformation driven by the viral oncoprotein E1A, demonstrating that SIRT7-mediated H3K18 de-acetylation is critical in mediating cellular transformation programs.10 In this regard, the up-regulation of SIRT7 in melanoma compared with nevus indicates that SIRT7 might also drive the malignant transformation of melanocytes to become melanoma cells, in addition to its role in melanoma cell malignant characteristics. This evidence concerns the gene SIRT7 and nevus.