To further elucidate the early phase of Paget’s disease, we subjected mice to skeletal phenotyping at 8 months of age, which corresponds to approximately 30 years in humans, considering that the initial PDB diagnosis in ZNF687-mutated patients is generally at approximately 45 years of age.14 Parametric analysis revealed significant bone mass reduction affecting the hind limbs and spine of mutant mice. This evidence concerns the gene ZNF687 and Paget disease.