Multiple findings support a role for angiogenesis and arterial development in modulating the spQRSTa, including candidate genes (ALDH1A2, ANGPT1, and VAV2), significant enrichment of GO-terms (coronary vascular development and vasculogenesis), and associations identified in PheWAS (arterial embolism, thrombosis and hypertension). The gene discussed is ANGPT1; the disease is Hypertension.