It also conferred a self-renewal advantage to HSCs and increased the reconstitution capacity after myeloablative conditioning.41 In addition to regulating normal HSCs, PTH has been shown to lead to different outcomes in murine models of CML (BCR-ABL1) and AML (MLL-AF9). The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.