MSCs can enhance spatial learning and prevent memory impairment in AD via various mechanisms including reducing Aβ plaques and tau hyperphosphorylation, reversing microglial inflammation, and promoting anti-inflammatory response.413 Currently, many clinical trials of MSCs in AD treatment have been approved (e.g., NCT03117738, NCT04040348, and NCT02672306). This evidence concerns the gene MAPT and Alzheimer disease.