NFKB1 and chronic kidney disease: Various drugs targeting SASP, like glucocorticoids, resveratrol and other protease inhibitors have been reported to attenuate CKD, and most of these mainly inhibit NF-κB signals and reduce ROS.430 Stem cell therapy has become the most likely effective therapeutic method to slow and even reverse CKD progression, in which MSC transplantation is widely explored due to their easy collection, low immunogenicity, and high paracrine potential.