Thereinto, monoclonal antibodies targeting IL-6 (Olokizumab: NCT02760407, NCT02760433, and NCT03120949; Clazakizumab: NCT02015520; Vobarilizumab: NCT02518620) have been registered for RA treatment, and other includes anti-IL-23 mAb (Mirikizumab: NCT03482011, NCT03535194, NCT03556202) and anti-IL17A/F mAb (Bimekizumab: NCT03598790 and NCT03766685) for psoriasis treatment, anti-IL-17 mAb (Secukinumab: NCT04181762) for SLE treatment, and anti-IL-23 mAb (Tildrakizumab: NCT03552276, NCT04314544, NCT04314531, NCT04991116) for PsA treatment. This evidence concerns the gene IL17A and rheumatoid arthritis.