They highlighted the report of gene expression changes of known ALS genes post-exercise in PBMCs from normal individuals where C9orf72 was downregulated significantly following acute exercise (fold change = −0.2, false discovery rate = 0.0002).57 They also reported that, when using the validated HAPAQ questionnaire, the age of onset was inversely proportional to levels of historical PA for C9orf72-ALS (Cox proportional hazards model, Wald test P = 0.007, likelihood ratio test P = 0.01, concordance = 74%) but not for non-C9orf72-ALS. Here, C9orf72 is linked to amyotrophic lateral sclerosis.