Comparison of the ECM proteins found enriched in obese mammary gland as compared with control mammary gland, in murine mammary tumors as compared with healthy mammary gland (121), and in highly metastatic versus poorly metastatic mammary tumor xenografts (107) and identified a 9-ECM-protein signature comprising collagens type VI and type XII, fibronectin, elastin, vitronectin, the laminin alpha 5 chain, annexin A3, galectin 1, and the von Willebrand Factor A Domain Containing 1 protein (120). The gene discussed is ELN; the disease is breast cancer.