6045 patients were eligible for the primary analysis, 4734 patients for the secondary analysis using the ESC hs-cTnT 0/1h-algorithm, and 4586 patients for the secondary analysis using the ESC hs-cTnI 0/1h-algorithm (see Supplementary material online, Figure S1). Patients with accompanying dyspnoea were older, more often female, and more often had known cardiovascular risk factors and known coronary artery disease (Table 1). The gene discussed is TNNI3; the disease is coronary artery disorder.