In fact, our data shows that there is decreased transcription of CREB-regulated gluconeogenic and lipogenic genes together with decreased glucose output and lipid accumulation in the presence of miR-98-5p; all suggestive of a crucial role of the miR-98-5p/PPP1R15B/eIF2α axis in deregulated hepatic metabolism as is evident in obesity, insulin resistance and diabetes. This evidence concerns the gene PPP1R15B and obesity due to melanocortin 4 receptor deficiency.