Once SARS-CoV-2 enters the gastrointestinal wall via ACE2 receptors, the inflammatory cells recruit and release pro-inflammatory cytokines, resulting in increased permeability, bacterial translocation, mucosal inflammation, and ACE2 dysfunction following post-obstructive appendicitis through the angioedema and stimulated hyperplasic lymphoid follicle [9, 21, 22]. The gene discussed is ACE2; the disease is angioedema.