While mice deficient for CD73 exhibited larger infarcts and increased immune cell infiltration into the ischemic hemisphere than wild-type mice after photothrombotic stroke [79], global CD73 deficiency did not affect infarct volume, immune cell infiltration, and glia cell activation profiles following ischemia-reperfusion injury induced by tMCAO in our laboratory [90]. The gene discussed is NT5E; the disease is stroke disorder.