P2RX4 and Stroke: Two studies highlight the need for a differentiated approach regarding timing and cell tropism: Sustained absence of P2X4 signaling, as occurring in P2X4ko mice, reduced infarct size after tMCAO, but myeloid cell-specific P2X4 deficiency led to more depressive behavior 30 days after stroke onset compared to recovering wild-type (WT) mice [23].