Consistent with the notion that platelet and fibrin accumulation occurs distal to the occluded vessel leading to microvascular thrombosis [87], CD39 knockout mice exhibited increased cerebral infarct volumes and reduced post-ischemic reperfusion after tMCAO [88], whereas treatment of WT mice with recombinant soluble human CD39 up to 3 h after induction of stroke reduced infarct sizes at 24 h and promoted an increase in post-ischemic blood flow [88]. This evidence concerns the gene ENTPD1 and stroke disorder.