First studies by Nancy Rothwell’s group did not show a difference in stroke size when comparing P2rx7-deficient and WT mice [35], and i.c.v. treatment with P2X antagonists oxidized ATP and PPADS immediately before and again 30 minutes (min) after tMCAO did not affect lesion size after tMCAO either [36]. The gene discussed is P2RX7; the disease is stroke disorder.