Studies using Brilliant Blue G (BBG) as P2X7 antagonist reported different outcomes regarding the role of P2X7 in rodent stroke models: The group of Carlos Matute reported that intraperitoneal BBG treatment 30 min after ischemia onset reduced the lesion size in rats subjected to tMCAO [40] and later reproduced their findings in mice [41]. This evidence concerns the gene P2RX7 and Stroke.