To clarify this apparent conflict and to delineate whether loss of GLUT1 expression in vivo causes disc degeneration, we used 2 mouse models, an inducible Glut1cKOK19 and constitutive Glut1cKOFoxa2, to determine a causal link between GLUT1 and intervertebral disc health. The gene discussed is SLC2A1; the disease is intervertebral disk degenerative disorder.