IGFBP7hi ECs were increased in SLE (IFN dominant) and scleroderma (IFN related), but not in AD (Th2 dominant) (Supplemental Figure 15, D and E), suggesting that IGFBP7hi ECs and IGFBP7-induced endothelial glycocalyx degradation may be more common in Th1-related skin diseases. Here, IGFBP7 is linked to Alzheimer disease.