We also treated HMEC-1 cells with psoriasis-related cytokines such as IL-17A, IL-22, IL-25, IFN-γ, TNF-α, and, VEGF-A, and among them, IFN-γ significantly upregulated the expression and secretion of IGFBP7 in HMEC-1 cells (Figure 8, B–D, and Supplemental Figure 9). The gene discussed is IL22; the disease is psoriasis.