In a previous study of monomicrobial sepsis using a bacterial infection model induced by Staphylococcus aureus, although survival in Plg–/– mice was reduced after inoculation of 1×107 CFU of S. aureus (61), these mice had increased survival rates when given a higher concentration of inoculum (1.6×108 CFU). The gene discussed is PLG; the disease is bacterial infectious disease.