PLG and Sepsis: Although other studies have shown that Plg/Pla does not affect neutrophil recruitment in simple models of self-resolving inflammation (21–23, 49), such as pleurisy and peritonitis elicited by thioglycolate, neutrophil recruitment is affected in more complex models of severe inflammation (50, 51), as in the preclinical models of sepsis used in our study, in which neutrophil accumulation was exacerbated in Plg–/– and uPAR–/– mice after CLP.