At this time point, multiple SASP factors, including connective tissue growth factor (Ctgf), platelet-derived growth factor, B polypeptide (Pdgfb), Tgfb, Il-6, and Tnfa, were also induced in post-RLDC kidneys (Supplemental Figure 1, E–J), further suggesting a sustained induction of tubular cell senescence throughout the development of cisplatin-induced CKD. Here, CCN2 is linked to chronic kidney disease.