After 1-week CORT treatment, when CORT-induced hyperinsulinemia and its reduction in GR-mKO mice were already observed (Figure 4E), an intraperitoneal insulin tolerance test (IPITT) implied CORT-induced insulin resistance had not improved in GR-mKO mice (Supplemental Figure 5, A and B). This evidence concerns the gene INS and Hyperinsulinemia.