In addition, STZ+ CORT+ GR-mKO mice exhibited slightly decreased but relatively preserved muscle mass compared with STZ− CORT+ GR-mKO mice (Figure 5I), indicating that muscle GR signaling is, at least to some extent, a vital cascade when counteracting muscle atrophy by hyperinsulinemia, as discussed later. Here, NR3C1 is linked to Hyperinsulinemia.