Plasma FGF21 levels of the CORT-treated group, however, were comparable between GRfl/fl and GR-mKO mice in both the fed and fasted states (Figure 4G), indicating that other axes rather than hepatic FGF21 production are probably dominant regulators in this obesity model. The gene discussed is FGF21; the disease is obesity due to melanocortin 4 receptor deficiency.