NCL was also highly expressed in CD105+ angiogenic ECs during fetal brain development and in GBM, with 75% and 74% CD105+/NCL+ double-positive ECs, respectively (Figure 1, G, I, and R), whereas only 13% CD105+/NCL+ ECs could be observed in adult brain slices (Figure 1, H and R), consistent with the reported quiescence of ECs in the adult normal brain (11, 56, 57). The gene discussed is ENG; the disease is glioblastoma.