In our study, we not only observed a reactivation of NCL in angiogenic endothelial and perivascular cells within glial brain tumors, but we also observed a positive correlation of NCL expression with astrocytic tumor progression, in agreement with ref. 99, suggesting a crucial role of NCL as a PVN-derived signal in both angiogenic and tumor growth. The gene discussed is NUCLEOLIN; the disease is neoplasm.