Reduction in MFN2 levels has been demonstrated in muscle and liver of diet‐induced obesity models (Gan et al, 2013; Gasier et al, 2020), prompting us to examine β‐cell MFN2 levels in islets isolated from two obesity models: high‐fat diet (HFD)‐fed mice and Zucker rats. Here, MFN2 is linked to Obesity.