Strikingly, our results demonstrated that a few inflammatory cytokines in the serum, including IL-2, IL-4, IL-6, IFN-γ, IL-1β, and TNF-α, were significantly downregulated in PCM patients after treatment of herbal drug combination compared to the CG treated with methylprednisolone (Figure 4). Here, IL6 is linked to paracoccidioidomycosis.