NF2 and malignant mesothelioma: Germline NF2 loss or inactivation is associated with neurofibromatosis type 2 syndrome, which results in the development of bilateral vestibular schwannomas, meningiomas, and ependymomas.10 Loss of merlin encoded by NF2 gene is found also in 40%-60% of sporadic meningiomas.25 In addition to tumors of the nervous system, NF2 GA alterations and merlin inactivation also occur in a large proportion of malignant mesothelioma (MM) patients.