PBRM1 and renal cell carcinoma: .31 In recent study of 14 NF2-mutated RCC cases, co-occurrence of NF2 and chromatin modulator PBRM1 GA was found in 5 (42%) cases.6 However, no NF2wt group was included in this study for comparison, and the number of cases was relatively small in contrast to our series.6 Although PBRM1 GA were found in 3.6% of NF2mut tumors in our study, the prevalence of this alteration was significantly lower as opposed to NF2wt group (25.1%).