For example, infection of IFNγ-stimulated human umbilical vein endothelial cells (HUVEC) with the type II, but not the type I, strain leads to ubiquitination and subsequent destruction of the PV by lysosomal fusion (21), whereas infection of IFNγ-stimulated HeLa cells with type II or type III, but not type I, strains causes growth stunting by noncanonical autophagy (22). This evidence concerns the gene IFNG and infection.