Cohen’s Kappa test comparing cancer-SIGVAR and vaRHC revealed significant differences for PM2 (kappa = 0.06, P-value = 2.98E−06), PM5 (kappa = 0.33, P-value = 1.34E−101), PP3 (kappa = 0.32, P-value = 9.91E−05), and BP4 (kappa = 0.47, P-value = 1.72E−07) criteria in CDH1 and PM1 (kappa = 0.48, P-value = 0), PM4 (kappa = 0.42, P-value = 3.08E−02), PM5 (kappa = 0.30, P-value = 2.63E−02), BP4 (kappa = 0.42, P-value = 4.49E−10), and BP7 (kappa = 0.35, P-value = 6.58E−03) in PTEN. The gene discussed is CDH1; the disease is cancer.