MSH2 and cancer: To our knowledge, our package outperforms tools available for several reasons: (i) it is the first freely available R package that semi-automates the process; (ii) it uses Tavtigian’s Bayesian metastructure nuanced by CanVIG-UK criterion combination rules, and (iii) it includes gene-specific guidelines for several commonly studied cancer genes, like ATM, CDH1, CHEK2, MLH1, MSH2, MSH6, PMS2, PTEN, and TP53.