Accordingly, we aimed to increase accuracy in variant classification by automated collection and combination of data, and assignation of several criteria according to gene-specific guidelines for ATM, CDH1, CHEK2, MLH1, MSH2, MSH6, PMS2, PTEN and TP53, and the updated general ACMG/AMP rules for other cancer susceptibility genes. This evidence concerns the gene CHEK2 and cancer.