The most commonly mutated genes comprised MUC16, CDC27, and MUC4 in the patients with type A thymoma, ZNF729, ZNF43, and MUC5B in type AB thymoma, MUC4, LILRB1, and TRIOBP in type B1 thymoma, SOHLH1, ZNF43, and MUC5B in type B2 thymoma, CDC27, MUC17, and MUC4 in type B3 thymoma, HRNR, CDC27, and MUC4 in TCs. This evidence concerns the gene MUC16 and thymoma.