In IDD, activation of the PI3K/Akt signalling pathway effectively ameliorated oxidative stress‐induced apoptosis, ECM degradation, and cell proliferation of NPCs118, 119 .In addition, Guo et al.120found that resveratrol (RSV) could promote ECM production and increase the expression of autophagy related markers (beclin‐1 and LC‐3) to induce cell autophagy to delay IDD. The gene discussed is MAP1LC3A; the disease is intervertebral disk degenerative disorder.