Consistent with this, multiple studies have shown that increased intracellular ROS can activate NF‐κB pathway and lead to NPCs inflammation, senescence, apoptosis, ECM degradation and mitochondrial dysfunction, while inhibition of NF‐κB pathway can reverse this phenomenon and delay IDD.39, 79, 140, 141. Here, NFKB1 is linked to intervertebral disk degenerative disorder.