In addition, small interfering RNAs against EMT transcription factors or key EMT-related genes have been used to inhibit cancer EMT, including Zinc-finger E-box-binding 1 (ZEB1), twist family bHLH transcription factor 1 (TWIST1), Nogo-B receptor and Wnt family member 1 (WNT1) [14–17]. Here, TWIST1 is linked to cancer.