SHBG and Dysmenorrhea: A controlled study of COC in the treatment of dysmenorrhea found that there was a significant negative correlation between dysmenorrhea and androgen levels such as T, dihydrotestosterone (DHT), dihydroepiandrosterone (DHEA), and COC significantly increased sex hormone binding globulin (SHBG) levels and significantly decreased DHT, DHEA and free androgen index (FAI) levels, but had no significant effect on T, E2 or FEI [44,45].