MKI67 and Alzheimer disease: In experiments utilizing proliferation markers, such as BrdU incorporation into newly-synthesized DNA and cell division-associated Ki67 staining, less than 3% of astrocytes responded with increased proliferation in an Alzheimer’s disease (AD) mouse model, and little to no proliferation was detected with treatment with lipopolysaccharide (LPS), an inflammatory signal [2, 54, 75, 142].