APOE and Alzheimer disease: Moreover, shared markers coinciding with DAM have been identified in a microglial subpopulation that shows upregulated TREM2 CD11c, APOE, LPL and CLEC7A, and downregulated TGFβ, TMEM119 P2RY12 and CSFR1 in aging and AD conditions [39, 44, 46].