The metabolic stress in NAFP, including insulin resistance and obesity, can stimulate severe acinar cell injury resulting in progressive acinar cell death, and acute pancreatitis, which acts as a trigger for various signaling mechanisms including the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway [4]. Here, CGAS is linked to obesity due to melanocortin 4 receptor deficiency.