Considering the consistency of the obtained data, it is concluded that HO-1 in CML cells is overexpressed by both CML cells and BMSCs of CML patients compared to healthy controls and that BCR-ABL activity induces HO-1 expression either by regulating NOX2 complex or induction of ROS formation due to increased metabolism. This evidence concerns the gene CYBB and chronic myelogenous leukemia, BCR-ABL1 positive.