The correlation between GFI-1 and HO-1 expression in AML patients was evaluated by Cheng et al. They found that HO-1 expression in relapsed patients' samples was higher compared to patients with complete remission or healthy controls, and was associated with HDAC1, HDAC2, and HDAC3 upregulation and was reversely correlated with GFI-1 expression. Here, HMOX1 is linked to acute myeloid leukemia.