Gene expression profiles from GEO datasets (GSE181508) indicated that Mmp19 was significantly increased in the lung endothelial cells of BLM-treated mice compared to normal controls, and Mmmp19 expression was positively correlated with vimentin expression, but negatively correlated with VE-cadherin expression (Additional file 3: Fig. S3). This evidence concerns the gene CDH5 and Bloom syndrome.