To further determine the role of ET1 in MMP19-induceded E(nd)MT, we evaluated the effect of BOS, which is an antagonist of the ET1 receptor, on MMP19-induced E(nd)MT and pulmonary fibrosis severity in the MMP19WT-AAV-infected mice after BLM instillation. This evidence concerns the gene MMP19 and pulmonary fibrosis.