In the correlation analysis, this study not only found that Nrg-4 was significantly positively correlated with HDL-C, just as a cross-sectional study found that serum Nrg-4 levels in T2DM patients were positively correlated with HDL-C, [24] but also found that Nrg-4 was positively correlated with HDL-C was significantly negatively correlated with FPG, HbA1C, TyG index, BMI and TG. This evidence concerns the gene NRG4 and type 2 diabetes mellitus.