In this study, it was found that the level of Asprosin was positively correlated with the TyG index, and was significantly increased in the T2DM-CHD group, indicating that IR is not only an important pathological basis of diabetes, but also an important cause of CHD, suggesting that Asprosin may be related to IR, and may play a role in the occurrence of CHD. This evidence concerns the gene FBN1 and diabetes mellitus.