The results revealed that the best cutoff value for circulating Asprosin to predict CHD was 19.008ng/ml (sensitivity: 66.2%, specificity: 71.2%, and AUC 0.671), and the best cutoff value for circulating Nrg-4 to predict CHD was 11.175ng/ml (sensitivity: 67.5%, specificity: 75%, and AUC 0.772) in patients with T2DM. This evidence concerns the gene FBN1 and type 2 diabetes mellitus.