NRG4 and type 2 diabetes mellitus: Compared with the T2DM-0 group, the serum Asprosin level in the T2DM-CHD group was significantly increased with 15.86 (13.24, 20.05)ng/ml in T2DM-0 vs. 22.63 (13.94, 27.97) ng/mL in T2DM-CHD, and the difference was statistically significant (p < 0.01).(Fig. 1A) The level of Nrg-4 was significantly decreased in the T2DM-CHD group with 13.38 (11.00, 17.18)ng/ml in T2DM-0 vs. 9.12 (7.55, 12.80) ng/mL in T2DM-CHD, and the difference was statistically significant (p < 0.01).