KDM1A and chronic obstructive pulmonary disease: In breast cancer cells, phosphorylation of LSD1 at 112th serine enhances the binding capacity and demethylation activity of LSD1 [23, 24], mutation from serine to alanine at this site exacerbates the pathogenesis of CSE/LPS-induced chronic obstructive pulmonary disease in mice [25] and inhibition of this phosphorylation alleviates colitis symptoms induced by dextran sulfate sodium [26].