TP53 and Hyperglycemia: It has been demonstrated that hyperglycemia (as it has been observed in the study) induces the downregulation of GLUT3, and that the inhibition of this transporter was able to suppress the tumorigenic potential of hepatocarcinoma cells, since GLUT3 is involved in different pathways such as cAMP, NF-κβ, and p53 signaling [36, 37].