Consistent with our ConsensusPathDB findings, Ingenuity Pathway Analysis (https://digitalinsights.qiagen.com/IPA)39 highlighted enrichment of cardiac hypertrophy signaling and osteoarthritis pathways and also implicated pulmonary and hepatic fibrosis signaling pathways, axonal guidance and PTEN signaling as well as the upstream regulators TGFB1 and IGF-1 (Supplementary Table 19). This evidence concerns the gene PTEN and Hepatic fibrosis.