SOS2 and Inguinal hernia: The missense SOS2 variant rs72681869 also showed association with SHBG; in both sexes, the G allele, associated with lower FVC and lower FEV1, was associated with lower SHBG, higher alanine aminotransferase (ALT) and aspartate aminotransferase (AST), higher fat mass, HbA1c and higher systolic and diastolic blood pressure, higher urate and creatinine, and in males lower testosterone and reduced inguinal hernia risk (Supplementary Fig. 13z–bb).