Comparisons of the GRSs of individuals across pairs of pathways for each of the 29 pathways (Supplementary Fig. 16a) and in detail for the elastic fiber, PI3K–Akt signaling, hypertrophic cardiomyopathy and signal transduction pathways (Supplementary Fig. 16b) demonstrated how GRS profiles may be concordant or discordant across pathways, which could have implications for the choice of therapy. The gene discussed is AKT1; the disease is hypertrophic cardiomyopathy.