ITGA2 and chronic obstructive pulmonary disease: The reduced expression of ITGA2 in lung tissue associated with the C allele of rs12522114 mimics vatelizumab-induced ITGA2 inhibition; this allele is associated with higher FEV1 and FEV1/FVC, indicating the potential to repurpose vatelizumab, which increases T regulatory cell populations37, for COPD treatment.