25 of 26 bladder cancer samples were labelled as DDRwt, with one labelled as BRCA2d due to a deep copy number deletion of BRCA2. Mutation and copy number calls from WES data mirrored original labels from deep targeted sequencing (Fig. 1b; Supplementary Data 3, 4). The gene discussed is BRCA2; the disease is urinary bladder carcinoma.