Interestingly, we found a positive correlation between hepatocyte senescence and CK19+HNF4α+ LPCs across 11 liver disease indications, with consistently higher percentages of both p21+ hepatocytes and LPCs in patients with cirrhosis compared to those with a non-cirrhotic milder form of the respective disease (Fig. 1j–m and Extended Data Fig. 6a). This evidence concerns the gene HNF4A and liver disorder.