Finally, to assess links between preeclampsia and placental cell types and their proportions, we applied our placenta cell type gene expression reference to deconvolute bulk placental tissues in a secondary data analysis of a case–control study33 of preeclampsia, including a mediation analysis of the preeclampsia-associated genes FLT1, LEP, and ENG that quantifies the role cellular composition plays in explaining bulk gene expression measures. Here, LEP is linked to preeclampsia.