Importantly, in the bleomycin-induced lung fibrosis model, in which stromal PDGF-C levels are elevated and the lung microenvironment is extensively activated (Fig. 2h and Extended Data Fig. 3e–g), TSAE1-shPdgfc and TSAE1-shNTC cells displayed comparable metastatic outgrowth (Fig. 4e). This evidence concerns the gene PDGFC and pulmonary fibrosis.