PDGFC and neoplasm: As previously shown (Fig. 4c), Pdgfc depletion in TSAE1 cells severely impaired metastatic outgrowth (Fig. 7d), and, when combined with imatinib treatment, there was a small but non-significant additional reduction in lung tumor cell content, likely due, at least in part, to imatinib inhibiting PDGFRα on fibroblasts that will respond both to tumor cell- and non-tumor cell-derived PDGF-C.