In particular, for AD, 19 microglial genes overlapped between PIGs [52] (plague-induced genes), DAM [22], and reversed genes, including Apoe, Fcer1g, C1qa, Frcls, C1qb, Itm2b, C1qc, Man2b1, Cd9, Olfml3, Cst3, Trem2, Ctsl, Ctsb, Ctss, Gusb, Ctsz, Hexa, and Cx3cr1 (Fig. 4d). The gene discussed is TREM2; the disease is Alzheimer disease.