In particular, for AD, 19 microglial genes overlapped between PIGs [52] (plague-induced genes), DAM [22], and reversed genes, including Apoe, Fcer1g, C1qa, Frcls, C1qb, Itm2b, C1qc, Man2b1, Cd9, Olfml3, Cst3, Trem2, Ctsl, Ctsb, Ctss, Gusb, Ctsz, Hexa, and Cx3cr1 (Fig. 4d). Here, C1QC is linked to Alzheimer disease.