In particular, for AD, 19 microglial genes overlapped between PIGs [52] (plague-induced genes), DAM [22], and reversed genes, including Apoe, Fcer1g, C1qa, Frcls, C1qb, Itm2b, C1qc, Man2b1, Cd9, Olfml3, Cst3, Trem2, Ctsl, Ctsb, Ctss, Gusb, Ctsz, Hexa, and Cx3cr1 (Fig. 4d). This evidence concerns the gene CTSL and Alzheimer disease.