EPHA1 and familial hypercholesterolemia: Further unbiased analysis of the healthy vessel proteome (based on Supplementary Data 2) is provided in Supplementary Data 4, highlighting networks enriched (p < 0.01) in “metabolism,” “muscle contraction,” “ECM organization,” “platelet activation, signaling, and aggregation,” and “EPH–ephrin and ROBO receptor signaling.” We show that, while all arteries are affected by systemic hypercholesterolemia, divergent pathways lead to plaque-free healthy arteries and diseased atherosclerotic arteries.