BRCA1 and neoplasm: To this end, we sought to further characterize the effects of NVB on the tumor immune microenvironment of Brca1-deficient TNBC and Brca2-deficient PDAC by IHC and flow cytometry, with particular emphasis on T-cell subsets given the induction of PD-L1 upon POLθ inhibition (Fig. 1).