The liver plays a key role in the regulation of whole-body energy metabolism, and targeting the liver attenuates HFD-induced obesity and diabetes18–20, we next crossbred ppp6r3fl/fl (FF) mice with a mouse line expressing Cre under the control of the liver-specific albumin promoter to generate liver-specific SAPS3 knockout mice (LKO) (Fig. 3a). The gene discussed is PPP6R3; the disease is obesity due to melanocortin 4 receptor deficiency.