To determine whether HER2 crosslinking induced by the trans binding of zanidatamab translates into distinct clustering geometries of HER2 on the surface of tumor cells, we used confocal microscopy to image Ab-induced HER2 spatial organization (detected using the monovalent anti-HER2 ECD1-AF647 OAA) in high HER2-expressing SK-BR-3 cells (Fig. 3). The gene discussed is ERBB2; the disease is neoplasm.