TGFB1 and neoplasm: Moreover, mIHC staining confirmed different expression levels of CD68+ &APOE+ macrophages, FOXP3+ &TNFRSF4+ Tregs, VEGFA, and TGFβ signaling between the tumor microenvironment of the de novo mild OLK and the OLK with moderate to severe dysplasia in clinical study (Fig. 7a, b).