During this period, the massive rapid secretion of proinflammatory cytokines, including IL-1β, IL-6, IL-12 and IL-23 [6,13], exacerbate the systemic inflammatory response and then cause multiorgan damages in severe cases [14]—especially to renal failure [15–17], and eventually promote the progression of sepsis to irreversible septic shock [6,13,18]. Here, IL1B is linked to Sepsis.