IL1B and Sepsis: Moreover, in the kidneys of infected mice, atp1Δ/Δ failed to cause an excessive transcription of the hyphae-specific proinflammatory cytokines IL-1β and IL-6 [7,11] as the same as WT, and significantly upregulated the transcription of the anti-inflammatory cytokine IL-4 that can control the progression of sepsis [19] when compared to WT.